VITENSKAP

Vår produktutvikling er basert på vitenskap. GenHealth er basert på tiår med ernæringsvitenskap. Vår innovasjon ligger ikke i levering av nye (og derfor ofte ikke fullt bevist) ingredienser. Vi vil gi deg velprøvde mikronæringsstoffer. Nedenfor er en liste over publikasjoner som danner grunnlaget for vårt produkttilbud. Vi oppfordrer deg til å finne fullstendige rapporter på www.pubmed.gov

➤ A variant of the HTRA1 gene increases susceptibility to age- related macular degeneration. Science. 2006 Nov 10.314(5801):992-3. Epub 2006 Oct 19. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K.
➤ Adams PC, R.D., Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P., Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med, 2005(352): p. 1769–78.
➤ Allen, K.J., et al., Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med, 2008. 358(3): p. 221-30.
➤ Alpha-tocopherol supplementation prevents the exercise- induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals.
➤ Am J Med. 1967; 42: 899-912
➤ American Heart Association
➤ Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial.
➤ Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women.
➤ Jacques PF, Kalmbach R, Bagley PJ, et al. The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr. 2002;132(2):283-288.
➤ Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
➤ Barbosa PR: Eur J Clin Nutr. 2008 Aug;62(8):1010-21. Epub 2007 May 23.
➤ Barry I. Posner2,12, David J. Balding13, David Meyre5, Constantin Polychronakos1,3 & Philippe Froguel5,14; A genome-wide association study
➤ Beja-Pereira, A.; Luikart, G.; England, P. R.; Bradley, D. G.; Jann, O. C.; Bertorelle, G.; Chamberlain, A. T.; Nunes, T. P.; Metodiev, S.; Ferrand, N.; Erhardt, G. :
➤ Bianchine, J. W.; Briard-Guillemot, M. L.; Maroteaux, P.; Frezal, J.; Harrison, H. E. : Generalized osteoporosis with bilateral pseudoglioma--an autosomal recessive disorder of connective tissue: report of three families--review of the literature. Am. J. Hum. Genet. 24: 34A only, 1972.
➤ Bolland MJ, Barber PA, Doughty RN, et al (2008). "Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial". BMJ 336: 262
➤ Bradley, L.A., J.E. Haddow, and G.E. Palomaki, Population screening for haemochromatosis: expectations based on a study of relatives of symptomatic probands. J Med Screen, 1996. 3(4): p. 171-7.

➤ Bundeslebensmittelschlüssel (BLS)
➤ Bulhoes, A. C., et. al. (2007-11). "Correlation between lactose absorption and the C/T-13910 and G/A-22018 mutations of the lactase-phlorizin hydrolase (LCT) gene in adult-type hypolactasia". Brazilian Journal of Medical and Biological Research.
➤ Burt, M.J., et al., The significance of haemochromatosis gene mutations in the general population: implications for screening. Gut, 1998. 43(6): p. 830-6.
➤ Calcium plus vitamin D supplementation and the risk of fractures.N Engl J Med. 2006 Feb 16;354(7):669-83. Jackson RD
➤ CDCP, Centers for Disease Control and Prevention
➤ Ch. 25, Disorders of the Eye, Jonathan C. Horton, in Harrison's Principles of Internal Medicine, 16th ed.
➤ Cholesterin, Risiko für Herz und Gefäße, Edita Pospisil, 2008
➤ Cholesterin, Wozu wir es brauchen und warum es uns krank macht, C.H.Beck, 1999 Dr. Ursel Wahrburg, Dr. Gerd Assmann

➤ Collins, D. R.; Knott, T. J.; Pease, R. J.; Powell, L. M.; Wallis, S. C.; Robertson, S.; Pullinger, C. R.; Milne, R. W. Marcel, Y. L.; Humphries, S. E.; Talmud, P. J.; Lloyd, J. K.; Miller, N. E.; Muller, D.; Scott, J. Truncated variants of apolipoprotein B cause hypobetalipoproteinaemia. Nucleic Acids Res. 16: 8361-8375, 1988

➤ Daniel Steinberg (2007). The Cholesterol Wars: The Cholesterol Skeptics vs the Preponderance of Evidence. Boston: Academic Press.

➤ de Jong PT (2006). "Age-related macular degeneration". N Engl J Med. 355 (14): 1474–1485.
➤ Defesche et al. 1998 FH workshop 1997
➤ Defesche, J. C.. Kastelein, J. J. P. : Molecular epidemiology of familial hypercholesterolaemia. (Letter) Lancet 352: 1643-1644, 1998

➤ Deutsche Gesellschaft zur Bekämpfung von Fettstoffwechselstörungen und ihren Folgeerkrankungen DGFF e.V

➤ Deutsche Ophthalmologische Gesellschaft (DOG)

➤ Deutsche Zöliakie Gemeinschaft
➤ Diagnosen am Augenhintergrund, Thieme, Bernd Kirchhof, Martin Reim, Sebastian Wolf, 2003
➤ DVO-Leitlinie "Osteoporose bei Frauen ab der Menopause und Männer ùber 60 Jahren", 2006
➤ Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
➤ Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
➤ Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.Dawson-Hughes B: N Engl J Med. 1997 Sep 4;337(10):670-6.
➤ Effect of supplementation of calcium and vitamin D on bone mineral density and bone mineral content in peri- and post- menopause women; a double-blind, randomized, controlled trial.Di Daniele N,Pharmacol Res. 2004 Dec;50(6):637-41.
➤ Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. Monsuur AJ, de Bakker PI, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A, van Heel DA, Crusius JB, Wijmenga C. PLoS One. 2008 May 28.3(5):e2270.
➤ Ellard, S. : Hepatocyte nuclear factor 1 alpha (HNF-1-alpha) mutations in maturity-onset diabetes of the young. Hum. Mutat. 16: 377-385, 2000
➤ Enattah, N. S.; Sahi, T.; Savilahti, E.; Terwilliger, J. D.; Peltonen, L.; Jarvela, I. : Identification of a variant associated with adult-type hypolactasia. Nature Genet. 30: 233-237, 2002.
➤ Fajans, S. S.; Bell, G. I.; Polonsky, K. S. : Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New Eng. J. Med. 345: 971-980, 2001.
➤ Farrell R, Kelly C. Celiac sprue. N Engl J Med 2002;346:180–8.
➤ Ferrari, S. L.; Deutsch, S.; Choudhury, U.; Chevalley, T.; Bonjour, J.-P.; Dermitzakis, E. T.; Rizzoli, R.; Antonarakis, S. E. : Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am. J. Hum. Genet. 74: 866-875, 2004
➤ Fracture prevention with vitamin D supplementation: a meta- analysis of randomized controlled trials.JAMA. 2005 May 11;293(18):2257-64: Bischoff-Ferrari HA
➤ Froguel, P.; Velho, G.; Cohen, D.; Passa, P. : Strategies for the collection of sibling-pair data for genetic studies in type 2 (non insulin-dependent) diabetes mellitus. (Letter) Diabetologia 34: 685 only, 1991
➤ Ganz DA, Bao Y, Shekelle PG, Rubenstein LZ (2007). "Will my patient fall?". JAMA 297 (1): 77–86
➤ Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nature Genet. 35: 311-313, 2003. Note: Erratum: Nature Genet. 35: 106 only, 2003.
➤ GeneticHealth.com.

➤ GFHEV-Leitlinien.
➤ Gidh-Jain, M.; Takeda, J.; Xu, L. Z.; Lange, A. J.; Vionnet, N.; Stoffel, M.; Froguel, P.; Velho, G.; Sun, F.; Cohen, D.; Patel, P.; Lo, Y.-M. D.; Hattersley, A. T.; Luthman, H.; Wedell, A.; St. Charles, R.; Harrison, R. W.; Weber, I. T.; Bell, G. I.; Pilkis, S. J. : Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc. Nat. Acad. Sci. 90: 1932-1936, 1993
➤ Guéant-Rodriguez RM: Thromb Haemost. 2005 Sep;94(3):510-5
➤ Guideline der National Osteoporosis Foundation (USA), 2003
➤ Guillaume Charpentier8, Thomas J. Hudson4,9, Alexandre Montpetit4, Alexey V. Pshezhetsky10, Marc Prentki10,11,
➤ Gut 1989; 30: 333-338
➤ Hadithi M: World J Gastroenterol. 2009 Feb 28;15(8):955-60.
➤ Hadithi M: World J Gastroenterol. 2009 Feb 28;15(8):955-60.
➤ Haemochromatose.org.
➤ Haines, J. L.; Hauser, M. A.; Schmidt, S.; Scott, W. K.; Olson, L. M.; Gallins, P.; Spencer, K. L.; Kwan, S. Y.; Noureddine, M.; Gilbert, J. R.; Schnetz-Boutaud, N.; Agarwal, A.; Postel, E. A.; Pericak-Vance, M. A. : Complement factor H variant increases the risk of age-related macular degeneration. Science 308: 419-421, 2005
➤ Handbuch Zöliakie, Österreichische Arbeitsgemeinschaft Zöliakie
➤ Hardwick, C. Prognosis in coeliac disease. Arch Dis Child 1939; 14:279.
➤ Hemochromatosis National Digestive Diseases Information Clearinghouse, National Institutes of Health, U.S. Department of Health and Human Services
➤ Hemochromatosis: Symptoms. Mayo Foundation for Medical Education and Research (MFMER). http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=2.
➤ Hemochromatosis: Treatments and drugs. Mayo Foundation for Medical Education and Research (MFMER).http://www.mayoclinic.c om/health/hemochromatosis/DS00455/DSECTION=7
➤ Herold, Innere Medizin 2008, 439-440
➤ HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. Europ. J. Hum. Genet. 16: 652-656, 2008

➤ Hobbs et al. 1992 Hum Mut 1:445
➤ Hobbs, H. H.; Brown, M. S.. Russell, D. W.; Davignon, J.. Goldstein, J. L. : Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. New Eng. J. Med. 317: 734-737, 1987
➤ Hopkins MH: Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):850-8. Epub 2010 Mar 3.
➤ http://www.ncbi.nlm.nih.gov/omim/125860
➤ identifies novel risk loci for type 2 diabetes; Nature, Vol 445|22 February 2007
➤ Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype.Caple F: Br J Nutr. 2010 Jan 19:1-9.
➤ Jackson RD, LaCroix AZ, Gass M, et al (2006). "Calcium plus vitamin D supplementation and the risk of fractures". N. Engl. J. Med. 354 (7): 669–83
➤ Kim DH, Vaccaro AR (2006). "Osteoporotic compression fractures of the spine; current options and considerations for treatment". The spine journal : official journal of the North American Spine Society 6 (5): 479–87
➤ Klein, R. J.; Zeiss, C.; Chew, E. Y.; Tsai, J.-Y.; Sackler, R. S.; Haynes, C.; Henning, A. K.; SanGiovanni, J. P.; Mane, S. M.; Mayne, S. T.; Bracken, M. B.; Ferris, F. L.; Ott, J.; Barnstable, C.; Hoh, J. : Complement factor H polymorphism in age-related macular degeneration. Science 308: 385-389, 2005
➤ Kuokkanen, M.; Kokkonen, J.; Enattah, N. S.; Ylisaukko-oja, T.; Komu, H.; Varilo, T.; Peltonen, L.; Savilahti, E.; Jarvela, I. : Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. Am. J. Hum. Genet. 78: 339-344, 2006.

➤ Kupper C (2005). "Dietary guidelines and implementation for celiac disease". Gastroenterology 128 (4 Suppl 1): S121–7.
➤ Laktose-Intoleranz, Thilo Schleip, 5.Auflage, 2003
➤ Leberkrankheiten_Informationswebseite.
➤ Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R, Collins R (December 2007). "Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths". Lancet 370 (9602): 1829–39.
➤ Lombardi et al. 1998 MEDPED 1998
➤ Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration.BMJ. 1998 Mar 21;316(7135):894-8
➤ Maller, J.; George, S.; Purcell, S.; Fagerness, J.; Altshuler, D.; Daly, M. J.; Seddon, J. M. : Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related 

macular degeneration. Nature Genet. 38: 1055-1059, 2006
➤ Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population.Tu HK: Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1089-97. Epub 2010 Mar 16.
➤ Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment.del Río Garcia C: Nutr Neurosci. 2009 Feb;12(1):13-20.
➤ Medicoconsult-Datenbank.
➤ MFMER, Mayo Foundation for Medical Education and Research.

➤ Montalto M, Curigliano V, Santoro L, et al (2006). "Management and treatment of lactose malabsorption". World J. Gastroenterol. 12 (2): 187–91. PMID 16482616. http://www.wjgnet.com/1007-9327/12/187.asp.
➤ Montezuma SR, Sobrin L, Seddon JM. Review of genetics in age related macular degeneration. Semin Ophthalmol. 2007;22:229-40.

➤ National Cholesterol Education Program (NCEP)
➤ National Digestive Diseases Information Clearinghouse (March 2006). "Lactose Intolerance". National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
➤ National Institutes of Health (NIH) - National Eye Institute
➤ Nature. 2007 Feb 22;445(7130):881-5. Epub 2007 Feb 11. A genome- wide association study identifies novel risk loci for type 2 diabetes. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G,Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P.
➤ NCEP, Nationales Cholesterin-Erziehungsprogramm
➤ NDDIC, National Digestive Diseases Information Clearinghouse.

➤ Niederau C, F.R., Pürschel A, Stremmel W, Häussinger D, Strohmeyer G, Long-term survivalin patients with hereditary hemochromatosis. Gastroenterology 1996(110): p. 1107-1119.
➤ NIH, Institutes of Health.
➤ ÖGTG – Österreichisches Gentechnik Gesetz
➤ Olds, L. C.; Sibley, E. : Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum. Molec. Genet. 12: 2333-2340, 2003.
➤ Olson RE (February 1998). "Discovery of the lipoproteins, their role in fat transport and their significance as risk factors". J. Nutr. 128 (2 Suppl): 439S–443S. PMID 9478044
➤ Philippe Boutin5, Daniel Vincent4, Alexandre Belisle4, Samy Hadjadj6, Beverley Balkau7, Barbara Heude7,
➤ Raisz L (2005). "Pathogenesis of osteoporosis: concepts, conflicts, and prospects.". J Clin Invest 115 (12): 3318–25
➤ Rayman MP: Proc Nutr Soc. 2005 Nov;64(4):527-42
➤ Redeker et al. 1998 EAS 98
➤ Report of a Joint WHO/FAO/UNU Expert Consultation(2002), Human Vitamin and Mineral Requirements, pp166-167
➤ Report of a Joint WHO/FAO/UNU Expert Consultation(2007) Protein and amino acid requirements in human nutrition, pp224-226
➤ Responsiveness of selenoproteins to dietary selenium.Allan CB: Annu Rev Nutr. 1999;19:1-16
➤ Richer SP.J Am Optom Assoc. 1993 Dec;64(12):838-50. Is there a prevention and treatment strategy for macular degeneration?
➤ Robert Sladek1,2,4, Ghislain Rocheleau1*, Johan Rung4*, Christian Dina5*, Lishuang Shen1, David Serre1,
➤ Rochette, J., et al., Multicentric origin of hemochromatosis gene (HFE) mutations. Am J Hum Genet, 1999. 64(4): p. 1056-62.
➤ Sblattero D, Berti I, Trevisiol C, et al (May 2000). "Human recombinant tissue transglutaminase ELISA: an innovative diagnostic assay for celiac disease". Am. J. Gastroenterol. 95 (5): 1253–7.
➤ Schmidt et al. 2000 Atheroscler 148: 431
➤ Scott, L. J.; Mohlke, K. L.; Bonnycastle, L. L.; Willer, C. J.; Li, Y.; Duren, W. L.; Erdos, M. R.; Stringham, H. M.; Chines, P. S.; Jackson, A. U.; Prokunina-Olsson, L.; Ding, C.-J.; and 29 others : A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345, 2007
➤ Seeman, E.; Hopper, J. L.; Bach, L. A.; Cooper, M. E.; Parkinson, E.; McKay, J.; Jerums, G. : Reduced bone mass in daughters of women with osteoporosis. New Eng. J. Med. 320: 554-558, 1989
➤ Selenium in cancer prevention: a review of the evidence and mechanism of action.
➤ Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection.Shilo S: J Inorg Biochem. 2008 Jan;102(1):110-8. Epub 2007 Aug 1.
➤ Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro.Ebert R: Stem Cells. 2006 May;24(5):1226-35. Epub 2006 Jan 19.

➤ Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.Hosoe K, Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. 
➤ Tong Y, Lin Y, Zhang Y, Yang J, Zhang Y, Liu H, Zhang B; Association between TCF7L2 gene polymorphisms and susceptibility to Type 2 Diabetes mellitus : a large Human Genome Epidemiology (HuGE) review and meta-analysis; BMC Med Genet. 2009 Feb 19;10:15
➤ Tsakiris S: Eur J Clin Nutr. 2009 Feb;63(2):215-21. Epub 2007 Sep 19.
➤ Tuula H. Vesa et al.: Lactose Intolerance, in: Journal of the American College of Nutrition, Vol. 19, No. 90002, 165S-175S (2000)

➤ Tybjaerg-Hansen A, Humphries SE. Familial defective apolipoprotein B-100: a single mutation that causes hypercholesterolemia and premature coronary artery disease. Atherosclerosis 1992.96:91-107
➤ van Vliet-Ostaptchouk, J. V.; Onland-Moret, N. C.; van Haeften, T. W.; Franke, L.; Elbers, C. C.; Shiri-Sverdlov, R.; van der Schouw, Y. T.; Hofker, M. H.; Wijmenga, C. :
➤ Varret, M.; Rabes, J.-P.; Collod-Beroud, G.; Junien, C.; Boileau, C.; Beroud, C. : Software and database for the analysis of mutations in the human LDL receptor gene. Nucleic Acids Res. 25: 172-180, 1997r M, Renner W, et al. Association of complement factor H Y402H gene orgy.